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pentobarbital will lower the level or outcome of alosetron by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.pentobarbital will decrease the extent or influence of lapatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital improves toxicity of buprenorphine, prolonged-per